| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3346078 | Current Opinion in Immunology | 2011 | 7 Pages |
Although national asthma guidelines help organize standards for asthma care, current asthma management is still primarily symptom based. Recent reports provide insights on how to improve asthma management through steps to better understand the natural history of asthma, individualize asthma care, reduce asthma exacerbations, manage inner city asthma, and some potential new ways to use available medications to improve asthma control. Despite many significant gains in managing asthma, we must now find improved strategies to prevent asthma exacerbations, alter the natural history of the disease, and to reduce health disparities in asthma care. Perhaps new directions in personalized medicine including a systems biology approach, along with improved health care access and communication will lead to better methods to alleviate the burden of asthma. This review will discuss the benefits and limitations of the current approach to asthma management, new studies that could impact new directions in asthma management, and new insights related to mechanisms of asthma and allergic airways inflammation that could eventually lead to improved asthma control.
► The primary risk factor for atopic asthma is sensitization to perennial aeroallergens. ► Anti-IgE (omalizumab) significantly attenuates seasonal peaks in asthma exacerbations. ► Worsening airflow limitation is associated with lower vitamin D levels in asthmatics. ► Bronchoconstriction in the absence of inflammation can induce airway remodeling. ► An altered airway innate immune response could be a link to persistent asthma.
