| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3346162 | Current Opinion in Immunology | 2012 | 7 Pages |
The diversity of B cell receptor (BCR) specificities is generated by VDJ recombination of gene segments during early B cell development, a process which bears the risk of producing BCRs that recognize and lead to the destruction of self-structures. Traditional thoughts have mainly focused on how such putatively dangerous specificities are dealt with and in how they contribute to the development of autoimmune diseases. However, a positive or even necessary role of self-recognition during B cell development has rarely been taken into account. Now, considerable data reveal that the pre-B cell receptor (pre-BCR), which marks an important checkpoint during B cell development, acts as a surrogate autoreactive receptor. This review outlines how autoreactivity is necessary for efficient B cell development and how autoreactive receptors drive positive selection, leading to a diverse repertoire of receptor specificities in the mature B cell pool.
► B cell receptor specificities are generated in a random process. ► Autoreactive specificities have been traditionally considered as harmful. ► New data identify the pre-B cell receptor as a surrogate autoreactive receptor. ► Self-recognition in B cell precursors is necessary for their efficient development. ► Autoreactivity contributes to the diversity of receptor specificities.
