| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3346284 | Current Opinion in Immunology | 2008 | 6 Pages |
Abstract
Recent advances have revealed new insights in cytokine regulation of inflammatory responses. TGFβ acting together with pro-inflammatory cytokines such as IL-6 promotes lineage commitment of RORγ-dependent Th17 cells. IL-23 – a member of the IL-12 family – activates the effector function of Th17 cells to promote skin, lung, and mucosal immunity. However, when dysregulated, these cells are important players in autoimmune inflammation. Unexpectedly, IL-27 – another IL-12 family member – plays an opposing role by inducing IL-10 production as well as downregulating both Th17 and Th1-mediated immune pathologies.
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Authors
Caroline Diveu, Mandy J McGeachy, Daniel J Cua,