| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3346563 | Current Opinion in Immunology | 2006 | 11 Pages |
Abstract
Somatic hypermutation and class-switch-recombination are initiated by the deamination of deoxycytosine in DNA by activation-induced-deaminase, AID. Recently, there has been much research into how AID targets double-stranded DNA in sub-regions of Ig genes, the involvement of co-factors and posttranslational modifications in this process, the co-option of DNA ‘repair’ mechanisms and AID evolution.
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Authors
Simonne Longerich, Uttiya Basu, Frederick Alt, Ursula Storb,