| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3347611 | Diagnostic Microbiology and Infectious Disease | 2009 | 5 Pages |
Abstract
We evaluated the pharmacokinetic/pharmacodynamic parameters of 8 oral quinolones (ciprofloxacin, garenoxacin [GRNX], gatifloxacin, levofloxacin, moxifloxacin, prulifloxacin, sitafloxacin, and sparfloxacin) on 11 fluoroquinolone-resistant Streptococcus pneumoniae strains, screened from 780 strains isolated from various clinical sources in Japan. GRNX showed the highest area under the blood concentration time curve/MIC ratios, which exceeded the target values for bacterial eradication against all fluoroquinolone-resistant S. pneumoniae strains.
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Authors
Shin-ichi Yokota, Yasuo Ohkoshi, Nobuhiro Fujii,