Article ID Journal Published Year Pages File Type
3347757 Diagnostic Microbiology and Infectious Disease 2008 5 Pages PDF
Abstract

Among orally administered cephalosporins, aminopenicillins (±clavulanate), and macrolides, cefditoren was the most potent agent against Haemophilus influenzae (MIC50/90, ≤0.008/0.03 μg/mL; 316 isolates including 100 β-lactamase–positive and 10 β-lactamase–negative ampicillin-resistant [BLNAR]) and was 32-, 64-, and 512-fold more potent than cefdinir, cefuroxime, and cefprozil, respectively. Cefditoren (MIC50, 0.03 μg/mL) was also ≥32-fold more active against BLNAR phenotypes, although newer macrolides provided complete coverage against these strains. All Moraxella catarrhalis isolates were inhibited by cefditoren (0.5 μg/mL), including β-lactamase producers (MIC50, 0.12 vs ≤0.008 μg/mL). Cefditoren retains potent activity against respiratory tract isolates in the United States, including those with resistance phenotypes.

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