| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3347782 | Diagnostic Microbiology and Infectious Disease | 2009 | 4 Pages |
Abstract
Human serum albumin (HSA) did not affect oritavancin MICs against non–vancomycin-intermediate Staphylococcus aureus (non-VISA) strains. In time–kill assays, oritavancin bactericidal activity in the presence of HSA was significantly more rapid than comparators against non-VISA strains. HSA increased oritavancin MICs by 4-fold for VISA strains, reflective of reduced oritavancin activity in time–kill assays with HSA.
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Authors
Francis F. Arhin, Geoffrey A. McKay, Sylvain Beaulieu, Ingrid Sarmiento, Thomas. R. Parr Jr., Gregory Moeck,