Extended-spectrum β-lactamase–type SHV-12–producing Enterobacteriaceae causing septicemia in Tanzanian children: vectors for horizontal transfer of antimicrobial resistance

Septicemia caused by extended-spectrum β-lactamase (ESBL)–producing Enterobacteriaceae was associated with high mortality in Tanzanian children. Conjugation experiments on the SHV-12–producing Enterobacteriaceae isolates showed that ESBL-encoding genes were transferred on large plasmids together with genes encoding resistance to aminoglycosides, resistance to ceftazidime, gentamicin, doxycycline, trimethoprim–sulfamethoxazole, and chloramphenicol.