Article ID Journal Published Year Pages File Type
3348428 Diagnostic Microbiology and Infectious Disease 2009 5 Pages PDF
Abstract

The impact of accessory gene regulator (agr) dysfunction and high bacterial density on vancomycin killing and resistance was evaluated among 10 clinical methicillin-resistant Staphylococcus aureus bloodstream isolates using time kill experiments. Under conditions of high inocula and agr dysfunction, vancomycin activity was markedly attenuated, amplifying resistant mutants by 72 h.

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Life Sciences Immunology and Microbiology Applied Microbiology and Biotechnology
Preview
Loss of vancomycin bactericidal activity against accessory gene regulator (agr) dysfunctional Staphylococcus aureus under conditions of high bacterial density
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