Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3348429 | Diagnostic Microbiology and Infectious Disease | 2009 | 4 Pages |
Abstract
In the past 2 to 3 decades, erythromycin resistance in Streptococcus pyogenes has been decreasing, whereas fluoroquinolone resistance (or reduction in its susceptibility) has been reported often. Although a shift of M-type prevalence and decreased pressure from macrolides have been suggested for the decrease in erythromycin resistance, we hypothesized that this might also be a result of increased antimicrobial pressure from fluoroquinolone use. Levofloxacin resistance for 4 erythromycin-resistant parent strains was induced in vitro. Their mutants became highly resistant to the fluoroquinolones but lost their erythromycin resistance trait. Erythromycin resistance was fully restored by transconjugation with respective parent strains with either mefA- or ermTR-mediated mechanisms.
Related Topics
Life Sciences
Immunology and Microbiology
Applied Microbiology and Biotechnology
Authors
Dewan Sakhawat Billal, Muneki Hotomi, Steve S. Yan, Daniel P. Fedorko, Jun Shimada, Keiji Fujihara, Noboru Yamanaka,