Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3348672 | Diagnostic Microbiology and Infectious Disease | 2008 | 4 Pages |
Abstract
We report the use of tigecycline, firstly with colistin and finally alone, in a patient with a persistent breakthrough bacteremia due to a Klebsiella pneumoniae isolate harboring a metallo-β-lactamase (VIM-1) and an extended-spectrum β-lactamase (SHV-12). Time-kill studies demonstrated that the combination of both compounds was synergistic along the first 12 h, suppressing the regrowth observed after 3 to 6 h when colistin was tested alone.
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Authors
Javier Cobo, María-Isabel Morosini, Vicente Pintado, Marta Tato, Noemí Samaranch, Fernando Baquero, Rafael Cantón,