| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3350178 | Human Immunology | 2014 | 7 Pages |
Abstract
Zhuang ethnic minority is the largest minority group in China. Here, we report for the first time the polymorphisms of MICA and MICB in a healthy Zhuang population of 209 unrelated individuals. Using polymerase chain reaction-sequence specific priming (PCR-SSP) and sequencing-based typing (PCR-SBT), 13 MICA-sequence alleles and 5 MICA-STR alleles, as well as 11 MICB alleles were detected, among which MICA∗010, MICA∗A5 and MICB∗005:02 were the most frequent alleles. Linkage disequilibria was investigated and the most common two-locus haplotypes were MICB∗005:02-MICA∗010 and MICB∗014-MICA∗045. These results suggest informative genetic markers for investigating origins and evolution of MHC class I region haplotypes in Zhuang population.
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Authors
E. Chen, L. Lin, C.J. Chen, X.Y. Zhang, Q.Z. Luo, P. Yu,