Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3350355 | Human Immunology | 2011 | 5 Pages |
Abstract
Results Single-marker analysis revealed that FCRL3 â169C/T was significantly associated with endometriosis (p = 0.004), regardless of the stage of the disease, p = 0.011 and p = 0.035, respectively to minimal/mild and to moderate/severe endometriosis. No association was found considering â110A/G, +358C/G, and +1381 A/G polymorphisms either for the endometriosis-related infertility group or the idiopathic infertility group. Haplotype analysis of four FCRL3 polymorphisms identified a haplotype GGGC associated with endometriosis (p = 0.026). The haplotype AGAT was associated with protection against endometriosis (p = 0.011) and infertility (p = 0.041). The data from this study point to a possible association of the FCRL3 â169C/T polymorphisms with endometriosis, especially minimal/mild endometriosis, and the haplotype AGAT may be protective against the development of the disease, in Brazilian women. However, these findings clearly need to be replicated in an independent sample and in different populations.
Related Topics
Life Sciences
Immunology and Microbiology
Immunology
Authors
Bianca Bianco, Juliana S. Teles, Tatiana G. Lerner, Fábia L. Vilarino, Denise M. Christofolini, Caio P. Barbosa,