Association between the SUMO4 M55V (A163G) polymorphism and susceptibility to type 1 diabetes: A meta-analysis

ObjectiveThe aim of this study was to determine whether the SUMO4 M55V (A163G) polymorphism confers susceptibility to type 1 diabetes (T1D).MethodsA meta-analysis was conducted on the association between the SUMO4 M55V polymorphism and T1D using; (1) allelic contrast (G vs. A), and the (2) recessive (GG vs. GA+AA), (3) dominant (GG+GA vs. AA), and (4) additive models (GG vs. AA).ResultsThirteen separate studies were considered in the meta-analysis, which in total included 5915 patients and 6660 controls, and five European and eight Asian sample populations. Europeans had a higher prevalence of the G allele than Asians (50.4% vs. 30.2%). Meta-analysis of the SUMO4 M55V polymorphism showed an association between T1D and the SUMO4 G allele in all study subjects (OR = 1.236, 95% CI = 1.112–1.373, p = 7.9 × 10−6), and stratification by ethnicity indicated a highly significant association between the SUMO4 G allele and T1D in Asians (OR = 1.303, 95% CI = 1.169–1.452, p = 1.78 × 10−7) and a marginal association with T1D in Europeans (OR = 1.177, 95% CI = 1.000–1.386, p = 0.050). Furthermore, significant associations were found between the SUMO4 M55V polymorphism and T1D and all study subjects, Europeans, and Asians using the dominant model (OR = 1.239, 95% CI = 1.144–1.342, p = 1.4 × 10−8; OR = 1.156, 95% CI = 1.051–1.271, p = 0.003; OR = 1.461, 95% CI = 1.262–1.691, p = 3.8 × 10−8, respectively).ConclusionsThis meta-analysis indicates that the SUMO4 M55V polymorphism confers susceptibility to T1D in Asians and Europeans.