| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3351436 | Human Immunology | 2012 | 4 Pages |
Abstract
T-bet is a transcription factor that drives the Th1 immune response primarily through promoting expression of the IFN-γ gene. Polymorphisms in the T-bet gene, TBX21, have been associated with immune-mediated diseases such as asthma and systemic sclerosis. We found that the TBX21 promoter polymorphism T-1993C is associated with a significant decrease in IL-4 and IFN-γ production by stimulated primary human lymphocytes from healthy participants.
Keywords
PFAUniversity of North Carolina at Chapel Hillphorbol 12-myristate 13-acetateIRBIFN-γHSVIL-4PBMCFBSnatural killerDNAPMAT-box expressed in T cellsEDTAEthylenediaminetetraacetic aciddeoxyribonucleic acidinterferon-γinterleukin-4T-betIntracellularRoom temperaturefetal bovine serumPeripheral blood mononuclear cellTH cellsT helper cellsinstitutional review boardpolymerase chain reactionPCRherpes simplex virusparaformaldehydeSingle nucleotide polymorphismSNP
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Authors
K.M. Fyall, A.M. Fong, S.B. Rao, J.G. Ibrahim, W.T. Waxweiler, N.E. Thomas,