| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3352306 | Human Immunology | 2008 | 5 Pages |
Abstract
We explored the possibility that antigen-specific human CD8+ T cells, which display cytotoxic or suppressor function, can recognize the same peptide epitope. Using the human leukocyte antigen-A0201 restricted immunodominant cytomegalovirus epitope pp65-NLVPMVATV for pulsing either mature/immunogenic or ILT3highILT4high tolerogenic dendritic cells (DC), we generated cytotoxic and suppressor CD8+ T-cell lines, respectively. Our data indicate that modulating the functional state of DC is crucial to the development of tolerogenic or immunogeneic peptide-specific vaccines.
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Authors
Haiyan Qin, George Vlad, Raffaello Cortesini, Nicole Suciu-Foca, John S. Manavalan,