Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3352549 | Human Immunology | 2007 | 5 Pages |
Abstract
SummarySevere bacterial infections are the major causes of morbidity and mortality in sickle cell anemia (SCA) but are poorly explained. The distribution of a bi-allelic polymorphism (Arg107Gly) of human leukocyte antigen–E (HLA-E) locus was investigated in 144 SCA patients, most of whom originated from from sub-Saharan Africa. Among them, 73 presented with at least one severe bacterial infection, whereas 71 did not. The HLA-E*0101/E*0101 genotype was more frequent among the group with infections than their counterparts (47% vs 21%; p corrected = 0.003). This genetic association is of relevance, given the emerging evidence for the involvement of HLA-E molecules in host response to pathogens.
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Authors
Ryad Tamouza, Marc Busson, Catherine Fortier, Ibrahima Diagne, Dapa Diallo, Ivan Sloma, Hector Contouris, Rajagopal Krishnamoorthy, Dominique Labie, Robert Girot, Dominique Charron,