| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3353143 | Immunity | 2013 | 10 Pages |
Abstract
A major function of a subfamily of NLR (nucleotide-binding domain, leucine-rich repeat containing, or NOD-like receptor) proteins is in inflammasome activation, which has been implicated in a multitude of disease models and human diseases. This work will highlight key progress in understanding the mechanisms that activate the best-studied NLRs (NLRP3, NLRC4, NAIP, and NLRP1) and in uncovering inflammasome NLRs.
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Authors
Haitao Wen, Edward A. Miao, Jenny P.-Y. Ting,