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CD28 Superagonists: What Makes the Difference in Humans?

Article ID Journal Published Year Pages File Type
3353994 Immunity 2008 5 Pages PDF
Abstract

In 2006, a clinical trial with the CD28 superagonistic antibody TGN1412 in London turned into a catastrophe. Studies are beginning to unravel the difference between the human and preclinical animal response to the antibody.

Related Topics
Life Sciences Immunology and Microbiology Immunology
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CD28 Superagonists: What Makes the Difference in Humans?
Authors
Burkhart Schraven, Ulrich Kalinke,
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