| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3355423 | Immunology Letters | 2014 | 4 Pages |
•Origins and lineages of B lymphocytes.•Development of hematopoiesis and of B lymphocytes from embryonic stem cells “in vitro”.•Development of B lymphocytes in fetal liver.
B lymphocyte development in the mouse begins with the generation of long-term reconstituting, pluripotent hematopoietic stem cells, over multipotent myeloid/lymphoid progenitors and common lymphoid progenitors to B-lineage committed pro/pre B and pre B cells, which first express pre B cell receptors and then immunoglobulins, B cell receptors, to generate the repertoires of peripheral B cells. This development is influenced and guided by cells of non-hematopoietic and hematopoietic origins. We review here some of the recent developments, and our contributions in this fascinating field of developmental immunology.
