Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3355498 | Immunology Letters | 2013 | 4 Pages |
Abstract
The study of in vitro and in vivo NK cell differentiation from hematopoietic precursors revealed the existence of discrete stages of development. These stages are characterized by the progressive acquisition of markers and receptors that play a crucial role in NK cell function. The knowledge acquired has revealed particularly relevant for improving the HSCT to cure high-risk leukemias in the haplo-HSCT setting, in which NK cells play a central role in the clearance of leukemic cells and in the positive clinical outcome.
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Authors
Elisa Montaldo, Paola Vacca, Lorenzo Moretta, Maria Cristina Mingari,