Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3355605 | Immunology Letters | 2012 | 12 Pages |
Psoriasis is a common chronic inflammatory skin disorder with dysregulation of miRNAs. The expression pattern of miR-146a and target gene IRAK1 in lesions and PBMCs of plaque psoriasis remains unclear. In our study, we found the expression of miR-146a was up-regulated both in lesions and PBMCs of psoriatic patients, and positively correlated with IL-17 expression, whereas the target gene IRAK1 expression was expressed differentially in lesions and peripheral blood. Inability of miR-146a inhibiting target gene IRAK1 may contribute to the persistent inflammation in lesions of psoriasis.
► miR-146a is a potential clinical marker in psoriasis. ► miR-146a plays an important role in IL-17 signal pathway in psoriasis. ► Dysregulation of miR-146a to IRAK1 may contribute to the pathogenesis of psoriasis.