Article ID Journal Published Year Pages File Type
3355846 Immunology Letters 2010 7 Pages PDF
Abstract

Mycobacterium bovis BCG is still the most widely used vaccine against tuberculosis and CD8+ T cells play important roles in fighting infection. We investigated how well antigen is processed and presented to CD8+ T cells using the same well-characterized CD8+ T cell epitope SIINFEKL expressed in either a cytoplasmic (GFP-OVA) or secreted (85B-OVA) context from BCG. We report that secreted SIINFEKL from 85B-OVA BCG is presented better than cytoplasmic SIINFEKL expressed by GFP-OVA BCG.

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Life Sciences Immunology and Microbiology Immunology
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