| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3356092 | Immunology Letters | 2009 | 8 Pages |
Abstract
During normal lymphocyte development, some adaptors show significant dynamics (gradual decrease of NTAL and increase of LAT and LIME during the T-cell maturation, decrease of PAG in B-precursors, high levels of LIME in peripheral B-lymphocytes). Analysis of childhood ALL samples revealed that in B-cell precursor ALL, the TEL/AML1 subgroup have unique adaptor profile compared to other leukemias. Moreover, NTAL expression separates T lineage leukemias into two subgroups with good and poor response to initial prednisone therapy showing prognostic impact of this molecule in T-ALL.
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Authors
Karel Svojgr, Tatiana Burjanivova, Martina Vaskova, Tomas Kalina, Jan Stary, Jan Trka, Jan Zuna,