| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 335612 | Psychiatry Research: Neuroimaging | 2007 | 5 Pages |
Abstract
Proton magnetic resonance spectroscopic imaging was performed to compare brain metabolism in patients with obsessive-compulsive OCD. Evaluation was done on responders and non-responders to pharmacotherapy and on healthy controls. The results showed significantly lower NAA/Cr ratios in the right basal ganglia in non-responders than in responders or in controls and higher Cho/Cr ratios in the right thalamus in non-responders than responders. Abnormal neuronal metabolism in the right basal ganglia and right thalamus may be indicating lack of response to treatment to selective serotonin reuptake inhibitor.
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Authors
Mona A. Mohamed, Mari A. Smith, Michael W. Schlund, Gerald Nestadt, Peter B. Barker, Rudolf Hoehn-Saric,