| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3356428 | Immunology Letters | 2006 | 4 Pages |
Abstract
The effect of priming with various antigens on subsequent vaccination with the pneumococcal conjugate vaccine (CPV) was determined using BALB/c mice. Priming with pneumococcal polysaccharide or cross-reactive polysaccharide did not inhibit the IgG response to CPV immunization. Additionally, live intranasal colonization by Streptococcus pneumoniae or cross-reactive organism resulted in higher IgG responses to CPV. These results suggest that colonization elicits immunological memory capable of boosting the immune response to CPV.
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Authors
Bradley Rabquer, S. Louise Smithson, Anne Shriner, M.A. Julie Westerink,