Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3356577 | Immunology Letters | 2006 | 7 Pages |
Abstract
Cotransplantation of donor bone marrow cells (BMCs) in allograft recipients is currently the most promising concept for clinical tolerance induction; however, it still has many difficulties in its successful performance due to the toxicity of the required host conditioning, the risk of engraftment failure, and the problem of graft-versus-host disease (GVHD), as well as the limited accessibility of donor bone marrow cells. Therefore, we performed the studies to determine whether BMCs from multi-donors are simultaneously engrafted and lead to induction of chimerism-based tolerance through the tolerogenic protocol of whom effectiveness we have shown in a previous study. Using a murine model, it was demonstrated that grafted BMCs from BALB/c (H-2d) and CBA mice (H-2k) establish mixed type and multi-lineage double chimerism and induce immunological donor-specific tolerance to fully MHC-mismatched skin allografts in host C57BL/6 mice (H-2b) receiving conditioning with Busulfan and treatment with the two-signal blockade comprised of anti-CD45RB and anti-CD154 monoclonal antibodies.
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Authors
Eun-Na Lee, Jienny Lee, Eun-Young Kim, Hae-Jung Park, Chi-Young Chang, Da-Yeon Jung, Su-Young Choi, Suk-Koo Lee, Jae-Won Joh, Choon-Hyuck Kwon, Jae-Hyung Noh, Sung-Joo Kim,