Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
335712 | Psychiatry Research: Neuroimaging | 2006 | 6 Pages |
Abstract
Earlier studies with functional imaging in schizophrenia have demonstrated dysfunction of the dorsolateral prefrontal cortex during working memory. Controlling for behavioral performance and for catechol-O-methyltransferase (COMT) Val158Met genotype, we here demonstrate in a functional magnetic resonance imaging paradigm that patients recruit greater neuronal resources in prefrontal cortex during working memory, suggesting that this phenotype is a core functional trait of the disease. We also replicated earlier findings that the Val allele of the COMT polymorphism is associated with greater engagement of the prefrontal cortex.
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Authors
Alessandro Bertolino, Grazia Caforio, Vittoria Petruzzella, Valeria Latorre, Valeria Rubino, Savino Dimalta, Alessandra Torraco, Giuseppe Blasi, Roberto Quartesan, Venkata S. Mattay, Joseph H. Callicott, Daniel R. Weinberger, Tommaso Scarabino,