Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3357578 | Indian Journal of Rheumatology | 2012 | 7 Pages |
Abstract
Juvenile dermatomyositis is the most common of the idiopathic inflammatory myositis of childhood. It is characterised by a pathognomic skin rash along with proximal muscle weakness. It may also affect organs other than the muscle and skin. Calcinosis and lipodystrophy are complications of long-standing untreated or poorly treated disease, associated with chronic morbidity. A variety of environmental and genetic risk factors are implicated in its pathogenesis. Up-regulation of genes by type-I interferon appears central. Corticosteroids along with methotrexate are the mainstay of therapy. Disease outcome is in general good.
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