Diagnosis and management of systemic sclerosis

Systemic sclerosis (Scleroderma, SSc) is associated with major mortality and morbidity that arises from the development of specific complications of the disease, including organ-based complications. The frequency and diverse nature of these complications makes systematic assessment and long-term follow-up essential to good management of SSc. This review will discuss the natural history of SSc, the predictors of progressive skin and internal organ involvement and current therapeutic management of these complications.