Late onset rheumatoid arthritis

Late onset rheumatoid arthritis (LORA) is a distinct subset of rheumatoid arthritis with age of onset over 60. It differs from young onset disease (YORA) by a more equal sex distribution, a higher frequency of abrupt disease onset, more large joint complaints and lesser extraarticular features. Different immunogenetic associations have been described. Disease modifying drugs and low doses of prednisone are the mainstream of therapy. Biologicals are increasingly being used with better efficacy and tolerability in recent studies.