Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3358677 | International Journal of Antimicrobial Agents | 2014 | 4 Pages |
Abstract
The in vitro activities of fluconazole (FLC), amphotericin B (AmB) and caspofungin (CSP) were evaluated against three isolates of Candida lusitaniae using time-kill curves. AmB showed in vitro fungicidal activity, whilst FLC and CSP exerted mainly strain-dependent fungistatic activity. The in vivo efficacies of the three drugs were evaluated in a murine model of disseminated infection. The doses administered were FLC 50Â mg/kg/day, AmB 0.8Â mg/kg/day and CSP 5Â mg/kg/day. All three drugs were able to reduce the fungal burden in the kidneys of infected mice, with AmB showing the highest efficacy, followed by CSP. At least in this model, FLC, AmB and CSP are good candidates for treating invasive infections by C. lusitaniae.
Related Topics
Life Sciences
Immunology and Microbiology
Applied Microbiology and Biotechnology
Authors
Marcelo Sandoval-Denis, F. Javier Pastor, Javier Capilla, Deanna A. Sutton, Annette W. Fothergill, Josep Guarro,