| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3359212 | International Journal of Antimicrobial Agents | 2013 | 5 Pages |
Abstract
Three enterobacterial isolates (two Klebsiella pneumoniae and one Escherichia coli) were recovered from three patients transferred from India to France in 2011. All three isolates were resistant or of intermediate susceptibility to all β-lactams and of decreased susceptibility to carbapenems. These three isolates expressed a novel carbapenem-hydrolysing β-lactamase, OXA-232, differing from OXA-181 and OXA-48 by one and five amino acid substitutions, respectively. Compared with OXA-181, OXA-232 had a lower ability to hydrolyse carbapenems but conversely possessed higher hydrolytic activities against penicillins. The blaOXA-232 gene was located on a 6.1-kb ColE-type non-conjugative plasmid.
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Authors
Anaïs Potron, Emilie Rondinaud, Laurent Poirel, Olivier Belmonte, Sophie Boyer, Sabine Camiade, Patrice Nordmann,