Article ID Journal Published Year Pages File Type
3359842 International Journal of Antimicrobial Agents 2010 8 Pages PDF
Abstract

Infection due to Acinetobacter baumannii has become a significant challenge to modern healthcare systems. The organism shows a formidable capacity to develop antimicrobial resistance, yet the clinical impact of A. baumannii infection remains unclear. Much is known about the processes involved in multidrug resistance, but those underlying the pathogenicity and virulence potential of the organism are only beginning to be elucidated. In this article, we provide an overview of current knowledge, focusing on mechanisms of pathogenesis, the molecular basis of resistance and options for treatment in the absence of novel therapeutic agents.

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Life Sciences Immunology and Microbiology Applied Microbiology and Biotechnology
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