Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3360878 | International Journal of Antimicrobial Agents | 2007 | 8 Pages |
Abstract
Diclofenac sodium (Dc), an anti-inflammatory agent, has remarkable inhibitory action both against drug-sensitive and drug-resistant clinical isolates of various Gram-positive and Gram-negative bacteria. The aim of this study was to determine the ability of Dc to protect mice from a virulent Salmonella infection. Dc injected at 1.5 μg/g and 3.0 μg/g mouse body weight significantly protected animals from the lethality of Salmonella infection. As was the case for the in vitro interaction, Dc in combination with streptomycin was even more effective. The non-antibiotic drug Dc has potential for the management of problematic antibiotic-resistant bacterial infections.
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Authors
Noton Kumar Dutta, Subramanian Annadurai, Kaushiki Mazumdar, Sujata G. Dastidar, Jette E. Kristiansen, Joseph Molnar, Marta Martins, Leonard Amaral,