Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3361061 | International Journal of Antimicrobial Agents | 2007 | 4 Pages |
Little is known about the in vitro activity of penems and carbapenems against the spirochete Borrelia burgdorferi. Here, faropenem, ertapenem, imipenem and meropenem as well as the third-generation cephalosporin ceftriaxone and tobramycin were tested in vitro against 11 isolates of the B. burgdorferi sensu lato complex. On a μg/mL basis, ertapenem was the most potent carbapenem (minimal inhibitory concentration (MIC) range: 0.015–0.125 μg/mL), with in vitro activity comparable with that of ceftriaxone against Borrelia. These findings are supported by the results of time–kill experiments in a Borrelia afzelii skin isolate, demonstrating a >3 log10 unit (99.9%) reduction of the inoculum after 96 h of exposure to either drug at a concentration of three log2 unit dilutions above the respective MIC.