| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3361245 | International Journal of Antimicrobial Agents | 2006 | 4 Pages |
Abstract
Azole resistance in Aspergillus spp. is unusual. We report a patient who received long-term treatment with itraconazole and voriconazole for bilateral chronic cavitary aspergillosis with aspergillomas whose isolates of Aspergillus fumigatus developed simultaneous resistance to itraconazole and voriconazole. A novel mutation (G138C) in the target gene (cyp51A) encoding 14α-demethylase was detected. The patient had some response to intravenous caspofungin, which he received six times weekly, without the development of resistance over 9 months.
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Authors
Susan J. Howard, Ian Webster, Caroline B. Moore, Rebecca E. Gardiner, Steven Park, David S. Perlin, David W. Denning,