Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3361559 | International Journal of Antimicrobial Agents | 2006 | 7 Pages |
Abstract
Genomic variations of rdxA and frxA genes in eight pairs of metronidazole (MTZ)-sensitive and -resistant isolates of Helicobacter pylori were investigated. The paired strains from each single biopsy had identical lspA-glmM restriction fragment length polymorphism profiles, and the differences in MTZ susceptibility were mostly accounted for by mutations in the rdxA gene. Truncation of RdxA is associated with a minimum inhibitory concentration of 64–128 mg/L. Early truncation of FrxA was observed both in susceptible and resistant isolates of seven paired strains. Inactivation of frxA might play a significant role only in one low-level MTZ-resistant isolate where a missense mutation was found in the rdxA gene.
Related Topics
Life Sciences
Immunology and Microbiology
Applied Microbiology and Biotechnology
Authors
Mario José Matteo, Cecilia Valeria Pérez, Mara Roxana Domingo, Martín Olmos, Cristian Sanchez, Mariana Catalano,