Article ID Journal Published Year Pages File Type
3364405 International Journal of Infectious Diseases 2009 5 Pages PDF
Abstract

SummaryObjectiveSerotypeable strains of Haemophilus influenzae, which can cause invasive infections, are found in the respiratory tract at low frequencies. We compared the antibiotic resistance of the typeable and nontypeable strains of H. influenzae in respiratory tract specimens obtained in Japan.MethodsWe determined the serotypes and the antibiotic susceptibilities of 440 clinical H. influenzae strains isolated from respiratory tract specimens. We also examined the prevalence of genotypes that are associated with β-lactam resistance.ResultsThe majority of the strains were nontypeable (421 strains, 95.7%). The remainder belonged to serotypes b (10 strains, 2.3%), e (three strains, 0.7%), or f (six strains, 1.4%). The type b strains exhibited the expression of β-lactamase and resistance mutations in penicillin-binding protein 3 with significantly higher frequencies than other strains.ConclusionsH. influenzae type b strains, which are associated with meningitis and bacteremia, derived from respiratory tract specimens, shared more β-lactam-resistant mechanisms than nontypeable and other serotype strains.

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Life Sciences Immunology and Microbiology Applied Microbiology and Biotechnology
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