Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3366348 | Joint Bone Spine | 2011 | 4 Pages |
Abstract
Paradoxical worsening of tuberculosis associated with immune reconstitution during antiretroviral therapy in patients with HIV infection is known as the immune reconstitution inflammatory syndrome (IRIS). Here, we report a case of paradoxical worsening of IFN-alpha induced tuberculosis in a patient experiencing reconstitution of pathogen-specific immune responses after discontinuing TNFα antagonist therapy. This case serves to alert clinicians that complications such as tuberculosis may worsen after TNFα antagonist discontinuation. This situation may paradoxically require readministration of the immunosuppressive drug in some patients.
Related Topics
Health Sciences
Medicine and Dentistry
Immunology, Allergology and Rheumatology
Authors
Claire Rivoisy, Lucile Amrouche, Guislaine Carcelain, Daniel Séréni, Anne Bourgarit,