Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3366904 | Joint Bone Spine | 2008 | 6 Pages |
Abstract
ObjectivesChondrocytes reside in a hypoxic environment; they utilize glucose as the main energy source. Facilitated glucose transport represents the first rate-limiting step in glucose metabolism.ResultsHere we demonstrated that hypoxia induced an elevated expression level of GLUT-1 and -3 in chondrocytes. Also elevated was hypoxia inducible factor-1α (HIF-1α) protein level. On the contrary, deletion of HIF-1α led to complete loss of the hypoxia-induced gene expression of GLUT-1 and 3.ConclusionThese results suggested that chondrocytes had the capacity to detect and respond to low oxygen availability with changes in expression of oxygen-regulated genes, and that hypoxia regulation of facilitated GLUT-1 and -3 was mediated by HIF-1α.
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Authors
Bu-Fang Ren, Lian-Fu Deng, Jun Wang, Ya-Ping Zhu, Li Wei, Qi Zhou,