Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3367863 | Journal of Autoimmunity | 2013 | 8 Pages |
Double negative T cells that lack the expression of both CD4 and CD8 T cell co-receptors exhibit a most unique antigen-specific immunoregulatory potential first described over a decade ago. Due to their immunoregulatory function, this rare T cell population has been studied in both mice and humans for their contribution to peripheral tolerance and disease prevention. Consequently, double negative cells are gaining interest as a potential cellular therapeutic. Herein, we review the phenotype and function of double negative T cells with emphasis on their capacity to induce antigen-specific immune tolerance. While the phenotypic and functional similarities between double negative T cells identified in mouse and humans are highlighted, we also call attention to the need for a specific marker of double negative T cells, which will facilitate future studies in humans. Altogether, due to their unique properties, double negative T cells present a promising therapeutic potential in the context of various disease settings.
► Immunoregulatory DN T cells present a unique antigen-specific mode of tolerance. ► A major challenge remains the identification of unique markers for these cells. ► Human DN T cells present a promising avenue in cell therapy.