| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3367869 | Journal of Autoimmunity | 2013 | 12 Pages |
Abstract
⺠Cell infiltrates orchestrate a perpetuating response underlying gland dysfunction. ⺠Th1 and Th17 cell products recruit additional lymphocytes, but also macrophages. ⺠Macrophages promote proteolysis, underlying tissue damage and inappropriate repair. ⺠Among the proteases is plasmin, generated by plasminogen activation through tPA. ⺠IFN drives tPA and plasmin cascade of proteolytic events in macrophages in vitro.
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Authors
Maria Gliozzi, Teresa Greenwell-Wild, Wenwen Jin, Niki M. Moutsopoulos, Efstathia Kapsogeorgou, Haralampos M. Moutsopoulos, Sharon M. Wahl,