| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 3367922 | Journal of Autoimmunity | 2012 | 7 Pages |
Abstract
⺠Epigenetic alterations are important in the pathogenesis of SLE. ⺠Epigenetic modifications and auto-antibody production may be linked. âºÂ Hypomethylated DNA is immunogenic and recognized by autoantibodies. ⺠Anti-histone antibodies bind preferentially epigenetic-sensitive hot spots. ⺠Epigenetically-modified ribonucleoprotein are important target for autoantibodies.
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Authors
Yosra Thabet, Felipe Cañas, Ibtissem Ghedira, Pierre Youinou, Rizgar A. Mageed, Yves Renaudineau,