Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3368342 | Journal of Autoimmunity | 2008 | 8 Pages |
Abstract
Interleukin (IL)-17 is a key inflammatory cytokine in autoimmune disease and may play an important role in the development of experimental autoimmune encephalomyelitis (EAE). In this study, we observed decreased IL-17 and increased IL-27 in EAE rats treated with bone marrow stromal cells (BMSCs). Neutralization of IL-27 resulted in recovery of the BMSCs effect. Adoptive transfer induction of EAE was poor by BMSC-stimulated MNCs, but could be induced by MNCs stimulated by BMSCs under blockade of IL-27 signaling. These results demonstrate that BMSCs may suppress the development of EAE, possibly via secretion of IL-27, which can inhibit IL-17 production or Th17 cell generation.
Keywords
Related Topics
Life Sciences
Immunology and Microbiology
Immunology
Authors
Jinghua Wang, Guangyou Wang, Bo Sun, Hulun Li, Lili Mu, Qi Wang, Guozhong Li, Lijun Shi, Lianhong Jin, Nikolaos Kostulas,