Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3368369 | Journal of Autoimmunity | 2008 | 7 Pages |
Abstract
Myelin proteolipid protein (PLP) is the most abundant protein in central nervous system (CNS) myelin and plays a major role in maintaining the structural and functional integrity of myelin. Its abundance in, and restriction to, CNS myelin and its post-translational modification by acylation make PLP an effective autoantigen, which can induce experimental autoimmune encephalomyelitis in rodents and non-human primates and which is a target of pathogenic autoimmunity in people with multiple sclerosis, a chronic inflammatory demyelinating CNS disease.
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Authors
Judith M. Greer, Michael P. Pender,