Article ID Journal Published Year Pages File Type
3371793 Journal of Hospital Infection 2013 11 Pages PDF
Abstract

SummaryBackgroundOral decontamination is proposed to be an effective prevention of ventilator-associated pneumonia (VAP).AimThe objective of this paper was to evaluate the effectiveness of oral decontamination in adult patients undergoing ventilation for more than 48 h.MethodsWe included all randomized controlled trials that used oral topical decontamination in adult patients from any population requiring mechanical ventilation for more than 48 h, versus placebo, normal saline, or standard oral care.FindingsSixteen trials involving 2399 participants were included. Meta-analysis showed that oral topical antiseptics significantly reduced the incidence of VAP [risk ratio (RR): 0.66; 95% confidence interval (CI): 0.49–0.88]. There was a significant reduction of VAP in studies which investigated decontamination with antibiotic agents other than iseganan (RR: 0.27; 95% CI: 0.18–0.42). Neither antiseptics nor antibiotics affected all-cause mortality, duration of ventilation, or duration of intensive care unit (ICU) stay.ConclusionOral decontamination reduced the incidence of VAP in adults undergoing ventilation, but did not affect all-cause mortality, duration of ventilation, or duration of ICU stay in ventilated patients. Further evidence from higher quality trials is necessary.

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