Article ID Journal Published Year Pages File Type
3373471 Journal of Hospital Infection 2008 10 Pages PDF
Abstract

SummaryFrom April 1996 to July 2004, an outbreak of metallo-β-lactamase-positive (MBL) Pseudomonas aeruginosa occurred in the haematology ward at Nantes University Hospital in France. Fifty-nine patients were carriers of VIM-2-positive strains of whom 14 were infected (mostly urinary tract infections and pneumonia). Pulsed-field gel electrophoresis identified related isolates demonstrating resistance to all β-lactams, aminoglycosides, fluoroquinolones, fosfomycin, rifampicin but not colistin. The blaVIM-2 gene responsible for VIM-2 MBL was not plasmid-encoded but part of a novel type of class 1 integron. VIM-2-positive strains were mostly from urine samples and clinical data suggest that in the absence of therapeutic guidelines, piperacillin–tazobactam or aztreonam may be a reliable choice for treating infections with MBL-producing strains.

Related Topics
Life Sciences Immunology and Microbiology Applied Microbiology and Biotechnology
Authors
, , , , , ,