Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
3375692 | Journal of Infection | 2007 | 6 Pages |
Abstract
SummaryFrom January 2002 to December 2003, 12 patients in a tertiary teaching hospital in northern Taiwan had bloodstream infections caused by Citrobacter freundii. Seven of the 12 isolates were resistant to cefotaxime. Using polymerase chain reaction and DNA sequencing, 3 of the 7 cefotaxime-resistant C. freundii isolates were found to carry extended-spectrum β-lactamase (ESBL). AmpC β-lactamase genes were also detected in all strains of C. freundii. All strains of C. freundii with MICs ≥4 mg/L for cefepime were positive for ESBL. Rather than performing PCR on all cefotaxime-resistant C. freundii isolates, assessment of the MIC for cefepime might be a practical way to choose between treatment with cefepime or with carbapenems.
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Authors
Chang-Pan Liu, Li-Chuan Weng, Hsiang-Kuang Tseng, Nai-Yu Wang, Chun-Ming Lee,