Article ID Journal Published Year Pages File Type
3375731 Journal of Infection 2008 10 Pages PDF
Abstract

SummaryBackgroundInhabitants of slum settlements represent a significant proportion of the population at risk for pneumococcal disease in developing countries.MethodsWe conducted a household survey of pneumococcal carriage among residents of a slum community in the city of Salvador, Brazil.ResultsAmong 262 subjects, 95 (36%) were colonized with Streptococcus pneumoniae. Children <5 years of age (OR, 8.0; 95% CI, 3.5–18.6) and those who attended schools (OR, 2.7, 95% CI, 1.2–6.0) had significantly higher risk of being colonized. Of 94 isolates obtained from colonized individuals, 51% had serotypes included in the seven-valent pneumococcal conjugate vaccine. Overall, 10% (9 of 94 isolates) were nonsusceptible to penicillin and 28% (27 of 94 isolates) were resistant to cotrimoxazole. BOX-PCR, PFGE and MLST analyses found that 44% of the carriage isolates belonged to 14 distinct clonal groups. Strains of the same clonal group were isolated from multiple members of 9 out of the 39 study households. Nineteen carriage isolates had genotypes that were the same as those identified among 362 strains obtained from active surveillance for meningitis.ConclusionsThe study's findings indicate that there is significant intra- and inter-household spread of S. pneumoniae in the slum community setting. However, a limited number of clones encountered during carriage among slum residents were found to cause invasive disease.

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